| Chemotherapeutic |
Dose |
Indication |
Remarks |
| Acetylsalicylic
acid |
50
grains/10 gallons prolonged bath |
relieves
shock and stress |
for
fresh and salt water |
| Acriflavin,
hydrochloride |
10
ppm for 2 hours |
protozoa,
bacteria, fungi |
not
as safe as Acriflavin (neutral) |
Acriflavin
(neutral)
.
|
5-10
mg/L prolonged bath 7-10 days continuous
_______________
500
mg/L 30 min bath daily ______________
25 mg/L 30 min daily for 15 days
|
protozoa
______________
bacteria
______________
antiviral |
kills
plants
_____________
none
______________
effective against Herpesvirus salmonis. Not effective orally.
Efficacy questionable |
| Ampicillin,
sodium |
|
bacteria |
not
effective. not advised. |
| Ampicillin
trihydrate |
|
bacteria |
not
effective. not advised. |
| Aspirin
|
50
grains/10 gallons prolonged bath |
relieves
shock and stress |
for
fresh and salt water |
| Atabrine
|
30
mg/L for 1 hour daily for 3 days
10
mg/L for 3 days, continuous
|
Cryptocaryon
irritans |
breaks
down in water quickly |
| Atabrine
hydrochloride |
30
mg/L for 1 hour daily for 3 days
10
mg/L for 3 days, continuous
|
Cryptocaryon
irritans |
breaks
down in water quickly |
| Aureomycin
|
13
mg/L for 5 min ONCE |
Oodinium
sp. |
questionable
efficacy |
| Bacitracin
|
60-75
mg/L indefinite |
bacteria |
not
absorbed systemically |
| Basic
Bright Green Oxalate |
60
mg/L for 45 seconds ONCE
1
mg/L for 2.5 hours
|
protozoa,
fungi |
none |
| Baslows
solution copper sulfate + TRIS buffer + EDTA) |
0.10
to 0.15 ppm ONCE |
Amyloodinium
and Cryptocaryon |
toxic
to freshwater fish |
| Betadine
|
|
|
not
advised |
| Bleach
. |
200
ppm for 1 hour |
antibacterial,
anti viral, antiprotozoal, anti fungal. Disinfectant |
Used
to sterilize tanks and equipment. Will kill fish and inverts. |
| Bright
green, zinc free
.
|
0.1%
painted on wound
67
mg/L for 1 min
0.2
mg/L for 1 hour
0.1
mg/L indefinite
0.1
mg/L OID Q3D
|
fungi
fungi
fungi
fungi,
some bacteria, ch, Cryptocaryon, Oodinium
fungi,
some bacteria, Ich, Cryptocaryon, Oodinium
|
Stains
skin asnd fabrics. Is mutagenic, teraogenic. May be toxic to some
species. More toxic at higher temperatures |
| Brilliant
green, zinc free |
0.1%
painted on wound
67
mg/L for 1 min
0.2
mg/L for 1 hour
0.1
mg/L indefinite
0.1
mg/L OID Q3D
|
fungi
fungi
fungi
fungi,
some bacteria, ch, Cryptocaryon, Oodinium
fungi,
some bacteria, Ich, Cryptocaryon, Oodinium
|
Stains
skin and fabrics. Is mutagenic, teraogenic. May be toxic to some species.
More toxic at higher temperatures |
| Chloramphenicol
|
|
|
not
effective as a bath |
| Chloramphenicol,
sodium succinate |
|
|
not
effective as a bath |
| Chloromycetin
|
|
|
not
effective as a bath |
| Chlorotetracycline
|
13
mg/L for 5 min ONCE |
antibacterial |
many
resistant strains |
| Chloroquine
|
10
mg/L indefinite, ONCE |
antiprotozoal,
control of Cryptocaryon irritans |
somewhat
effective |
| Chloroquine
diphosphate |
10
mg/L indefinite, ONCE |
antiprotozoal,
control of Cryptocaryon irritans |
somewhat
effective |
| Copper,
buffered (copper sulfate + TRIS buffer + EDTA) |
0.10
to 0.15 ppm ONCE |
Amyloodinium,
Cryptocaryon |
toxic
to freshwater fish |
| Copper
sulfate . |
0.0001
mg/L indefinite, continuous
bath
500 mg/L for 1 minute
2.3
to 4.0 mg/L indefinite
|
protozoa
protozoa
algae
control
|
toxic
to inverts and live plants. Prolonged exposure may cause anemia. kidney,
liver and gill problems over time. Highly toxic to freshwater fish. |
Copper sulfate, citrated |
0.15
to 0.20 mg/L for 14 days |
protozoa
|
toxic
to inverts and freshwater fish. Perhaps the most effective form of
copper. |
Copper
sulfate, chelated
|
2
mg/L to 8 mg/L |
protozoa
|
generally
not as effective as non chelates. Prolonged exposure may cause anemia,
gill, kidney and liver damage. Not advised. |
| Cycloserine.
|
50
mg/gal every other day for 3 treatments |
bacteria,
possibly fish tuberculosislosis |
Saltwater
only |
| Calcium
hypochlorite |
200
ppm for one hour
300
ppm
|
antibacterial,
antiviral, antifungal, antiprotozoal, disinfectant.
effective
against Myxosoma
|
Will
kill fish and inverts. For sterilization ONLY |
| Daraprim |
1
ppm |
Cryptocaryon,
Ich |
not
effective |
| Dichlorvos
|
0.2
mg/kg continuous (for 4 weeks) |
monogenea,
digenea crustaceans |
none |
Dimetridazole
.
|
50
mg/L for 24 hours. Repeat daily for 10 days |
Hexamita |
not
very effective |
| Dimilin
|
0.01
mg/L 48 hours. 3 treatments, 6 days apart. |
crustaceans |
76%
of this chemical persists at least one week in pond water |
Dylox
|
0.25
mg/L for 1 hr. every 5 days
0.5
mg/L for 1 hr. every 5 days
2.0
mg/L for 1 hr., ONCE
|
trematodes,
crustaceans |
potentially
carcinogenic. Doses are in active ingredient. Water to be discarded
should be brought to pH 11 |
Epsom
salts
|
70
g/L for 5 min ONCE |
cathartic |
freshwater
fish only |
| Erythromycin
|
50
mg/L for 15 min
250
mg/ 25 gallons, indefinite
|
antibacterial
Cyanobacter
control
|
ineffective.
not advised
will
not harm biological filter at this dose
|
| Flagyl
|
4
mg/L for 3 to 4 days |
Hexamita |
change
water with each treatment. poorly soluble |
| Flumequine
|
50
mg/L for 30 minutes |
Furunculosis
|
absorption
increased at lOver pH. |
| Formaldehyde
(37%)
.
.
|
0.4
ml/L up to 1 hour every 3 days in soft water.
0.5
ml/L up to 1 hour every three days in hard water
2
ml/L in marine water up to 1 hour every three days
|
protozoa,
monogenea, digenea, crustaceans |
effect
on fish is highly species specific. Not advised. Wear protective eye
wear when using. POISON! |
| Fresh
water |
immerse
marine fish for 5 to 10 min |
extoparasites,
protozoa |
not
for fishes with lesions |
Furacin
|
2
ppm as a 24 hour bath
10
ppm as as 24 hour bath
|
bacteria,
antiseptic |
not
effective against Ich |
| Furanace
|
0.05
to 0.1 mg/L indefinite bath |
bacteria
|
non-food
fish only |
| Furazone
green |
2
ppm as a 24 hour bath
10
ppm as as 24 hour bath
|
bacteria,
antiseptic |
not
effective against Ich |
| HTH
. |
200
ppm for one hour
300
ppm effective against _Myxosoma_.
|
antibacterial,
antifungal, antiviral, antiprotozoal disinfectant |
Will
kill fish and inverts. FOR STERILIZATION ONLY! |
| Hydrocortisone
|
10
mg/L 30 minutes MAXIMUM as needed |
shock |
none |
| Hydrogen
peroxide, 3% |
17.5
gm/ L for 10-15 min bath
5000
ppm dip for 5 min
1
ml/10 gallons/hour
|
ectoparasites,
protozoacide
antiseptic
oxygen
enhancer
|
may
disrupt biological filter with prolonged use. |
Iodine
7% tincture
|
paint
on wound and rinse immediately |
antiseptic
|
none |
| Ipropan
|
3-4
mg/L for 6-12 hours ONCE |
Hexamita |
none |
| Isoniazid.
|
40
mg/ gal for three treatments, every other day |
bacteria.
Possibly effective against marine tuberculosis |
none |
| Kanamycin
|
750
mg/L for 2 hours OID |
bacteria
|
none |
| Levamisol
.
|
2
mg/L for 24 hours ONCE
50
mg/L for 2 hours ONCE
|
nematodes |
most
effective against larval nematodes, swimbladder worms no increase
in effectiveness with higher dose. LD50 for eels is 250 mg/. Single
treatment kills ~ 50% of nematode load. |
| Magnesium
sulfate |
70
g/L for 5 min ONCE |
cathartic |
freshwater
fish only |
| Malachite
green, zinc free
.
|
0.1%
painted on wound
67
mg/L for 1 min
0.2
mg/L for 1 hour
0.1
mg/L indefinite
0.1
mg/L OID Q3D for three treatments
|
fungi
fungi,
some bacteria, Ich, Cryptocaryon, Oodinium
|
Stains
skin and fabrics. Is mutagenic, teraogenic. May be toxic to some species
if overdosed. More toxic at higher temperatures. |
| Malachite
green, zinc free plus formalin |
0.1
mg/L indefinite
0.1
mg/L OID Q3D for three treatments
|
fungi,
some bacteria, Ich, Cryptocaryon, Oodinium |
Stains
skin and fabrics. Is mutagenic, teraogenic. May be toxic to some species
if overdosed. More toxic at higher temperatures. Formalin may disrupt
biological filter. NOT ADVISED. |
Marine
salt
|
22
g/L for 30 min
30
g/L for 10 min
1-3
g/L indefinite
6
g/L indefinite
|
protozoa,
fungi, Epistylis, osmoregulatory stress |
none
none
subtherapeutic
level
"general
tonic"
|
Masoten
|
0.25
mg/L for 1 hr. every 5 days
0.5
mg/L for 1 hr. every 5 days
2.0
mg/L for 1 hr., ONCE
|
trematodes,
crustaceans |
potentially
carcinogenic. Doses are in active ingredient. Water to be discarded
should be brought to pH 11 |
Mebendazole
|
1
mg/L for 24 hours ONCE
100
mg/L for 2 hours ONCE
|
Pseudodactylogyrus |
none |
| Merbromen
|
paint
on wounds |
disinfectant |
do
not get into gills |
| Mercurochrome
|
paint
on wounds |
disinfectant
|
do
not get into gills |
| Merthiolate |
paint
on wounds |
disinfectant,
fungi, bacteria |
rinse
fish before returning to tank. Do not get into gills. |
| Methylene
Blue |
2
mg/L prolonged bath up to 5 days, continuous
3
mg/L prolonged bath up to 5 days, continuous
50
mg/L for 10 seconds
|
Cyanide
toxicity,
oxygen
transfer across gills
fungi
|
May
kill plants. Harmful to biological filter. Will stain hands and fabrics.
Effectiveness reduced by organics in tank.
none
|
| Metronidazole
|
4
mg/L for 3 to 4 days |
Hexamita |
change
water with each treatment. Poorly soluble |
Micromycin
|
400
mg/L for 1 hr. daily for 7 days
100
mg/L for 1 hr. daily for 7 days
|
bacteria
bacteria
|
saltwater
fish only
freshwater
fish only
|
| Minocycline
|
100
mg/10 gallons every other day |
bacteria |
possibly
effective against fish tuberculosis |
MS-222
|
50
to 100 mg/L
250
to 500 mg/L
|
tranquilizer
euthanizing
solution
|
use
with caution. Dose is species specific. |
| Neguvon
|
0.25
mg/L for 1 hr. every 5 days
0.5
mg/L for 1 hr. every 5 days
2.0
mg/L for 1 hr., ONCE
|
trematodes,
crustaceans |
potentially
carcinogenic. Doses are in active ingredient. Water to be discarded
should be brought to pH 11 |
| Nifurpirinol
|
0.05
to 0.1 mg/L indefinite bath |
bacteria |
non
foodfish only |
Nitrofurazone
|
2
ppm as a 24 hour bath
10
ppm as 24 hour bath
|
bacteria,
antiseptic |
not
effective against Ich |
| Nitrofurpyrinol
|
2
mg/L for 19 hours ONCE |
antiprotozoal
|
effective
against Chilodonella. Not effective in salt water. Not effective
against Ich. Can cause skin and gill lesions in catfish. Mutagenic
and carcinogenic. |
| Oxytetracycline
|
400
mg/L for 1 hr. daily for 7 days
100
mg/L for 1 hr. daily for 7 days
|
bacteria |
saltwater
fish only
freshwater
fish only
Many
resistant strains
|
| Oxytetracycline
hydrochloride |
400
mg/L for 1 hr. daily for 7 days
100
mg/L for 1 hr. daily for 7 days
|
bacteria |
saltwater
fish only
freshwater
fish only
Many
resistant strains
|
| Ozone
|
0.1
mg/L for 60 sec. daily for 7 days
70
mg/L for 10 min daily for 7 days
90
mg/L for 10 min daily for 7 days
0.1
mg/L continuous.
|
disinfectant,
antibacterial, antiviral, antiprotozoal. Oxidizes organics. |
use
with caution. Can burn mucus membranes. Degrades rubber. Run ozonated
water through carbon before returning to tank. Concentration must
be checked daily or ozonator should be regulated by an ORP meter (preferred) |
Phenoxyethol
|
100
mg/L as a 1 hr. bath, ONCE |
fungi |
none |
2-Phenoxyethol
|
100
mg/L as a 1 hr. bath, ONCE |
fungi |
none |
Potassium permanganate |
1
g/L for 30-40 seconds.
20
mg/L for 1 hr.
2-5
mg/L indefinite
|
crustaceans,
protozoa |
Only
in acid water. Can be toxic to goldfish.
food
fish use.
Can
cause massive fish deaths. Not advised.
|
| Povidone-Iodine
|
|
|
not
advised |
| Praziquantel
HCL , |
10
mg/L for 3 hours
2
mg/L for 24 hours
|
trematodes,
cestodes, Dactylogyrus, Diplozoon, Proteocephalus |
Levels
can cause toxicity in Corydoras catfish. Not advised for
juvenile fishes. Fish may appear narcotized after dip. Not easily
dissolved in water. Repeat treatment at weekly intervals for 3 weeks
for egg laying monogenes. |
| Primaquine
phosphate |
15
mg/gal every other day for 5 treatments |
Cryptocaryon |
salt
water only |
| Pyrimthamine |
1
ppm |
Cryptocaryon,
Ich |
not
effective |
Quinaldine
|
20:1
with ethyl alcohol |
fish
tranquilizer |
not
advised due to alcohol content |
| Quinacrine
|
30
mg/L for 1 hour daily for 3 days
10
mg/L for 3 days, continuous
|
Cryptocaryon
irritans |
breaks
down in water quickly |
| Quinacrine
hydrochloride |
30
mg/L for 1 hour daily for 3 days
10
mg/L for 3 days, continuous
|
Cryptocaryon
irritans |
breaks
down in water quickly |
| Quinine
hydrochloride |
30
mg/L for 1 hour daily for 3 days
10
mg/L for 3 days, continuous
|
Cryptocaryon
irritans |
breaks
down in water quickly |
Quinine sulfate |
30
mg/L for 1 hour daily for 3 days |
protozoa |
breaks
down quickly in water |
| Salt
water |
2
ppt as an indefinite bath |
protozoa,
fungi, Epistylis, osmoregulatory stress |
none |
| Sea
water |
2
ppt as an indefinite bath |
protozoa,
fungi, Epistylis, osmoregulatory stress |
none |
| Simazine
|
0.5-2.5
g/m3 indefinite |
herbicide,
algicide |
food
fish use. Will kill trees. |
Sodium
chloride
|
22
g/L for 30 min
30
g/L for 10 min
1-3
g/L indefinite
6
g/L indefinite
|
protozoa,
fungi, Epistylis, osmoregulatory stress |
none
subtherapeutic
level
"general
tonic"
|
| Sodium
chlorite |
2-5
ppm indefinite |
bacteria,
protozoa |
freshwater
use only. May kill plants |
| Sodium
hypochlorite |
200
ppm for 1 hour |
antibacterial,
anti viral, antiprotozoal, anti fungal . Disinfectant. |
Used
to sterilize tanks and equipment. Will kill fish and inverts. |
| Sodium
sulfadiazine |
100
to 250 mg/L as a long duration bath |
bacteria |
will
precipitate in water <pH 9. Repeat each day for 5 days. Good for
one day. May be effective against Cryptocaryon |
| Sodium
sulfathiazole |
250
mg/10 gallons as a long duration bath |
bacteria |
will
precipitate in water <pH 9. Repeat each day for 5 days. Good for
one day. May be effective against Cryptocaryon |
| Sodium
thiosulphate |
1
gram/ 10 gallons |
chlorine
neutralizer |
none |
| Sulfadiazine
|
250
mg/10 gallons as a long duration bath |
bacteria |
will
precipitate in water <pH 9. Repeat each day for 5 days. Good for
one day. May be effective against Cryptocaryon |
| Sulfamethazine
|
100
mg/L for 1 hour daily for 7 days |
bacteria |
none |
| Sulfathiazole
sodium |
250
mg/10 gallons as a long duration bath |
bacteria |
will
precipitate in water <pH 9. Repeat each day for 5 days. Good for
one day. May be effective against Cryptocaryon |
| Sweet
water |
immerse
marine fish for 5 to 10 min |
extoparasites,
protozoa |
not
for fishes with lesions |
Table
salt, non-iodized
|
22
g/L for 30 min
30
g/L for 10 min
1-3
g/L indefinite
6
g/L indefinite
|
protozoa,
fungi, Epistylis, osmoregulatory stress |
none
subtherapeutic
level
"general
tonic"
|
| Terramycin
|
400
mg/L for 1 hr. daily for 7 days
100
mg/L for 1 hr. daily for 7 days
|
bacteria |
Saltwater
fish only
Freshwater
fish only
Many
resistant strains.
|
| Tetracycline
|
400
mg/L for 1 hr. daily for 7 days
100
mg/L for 1 hr. daily for 7 days
|
bacteria |
Saltwater
fish only
Freshwater
fish only
Many
resistant strains
|
| Tetracycline
HCL |
400
mg/L for 1 hr. daily for 7 days
100
mg/L for 1 hr. daily for 7 days
|
bacteria |
Saltwater
fish only
Freshwater
fish only
Many
resistant strains.
|
| Tincture
of iodine 7% |
|
antiseptic
|
Paint
on wound and rinse immediately |
| Tricaine
methsulfonate |
15-66
mg/L 6-48 hours
50-330
mg/L 1-40 minutes
|
sedation
anesthesia
|
use
with caution |
Trichlorfon
|
0.25
mg/L for 1 hr. every 5 days
0.5
mg/L for 1 hr. every 5 days
2.0
mg/L for 1 hr., ONCE
|
trematodes,
crustaceans |
potentially
carcinogenic. Doses are in active ingredient. Water to be discarded
should be brought to pH 11 |
| TRIS
buffer (copper sulfate + TRIS buffer + EDTA) |
0.10
to 0.15 ppm ONCE |
Amyloodinium
and Cryptocaryon |
toxic
to freshwater fish |
| Vancomycin |
2.0
mg/l for one hour, ONCE |
bacteria
(gram positive cocci) |
has
a shelf life of two weeks when in solution. |
| Vancomycin
hydrochloride |
2.0
mg/l for one hour, ONCE |
bacteria
(gram positive cocci) |
has
a shelf life of two weeks when in solution. |
Victoria
Green
|
0.1%
painted on wound
67
mg/L for 1 min
0.2
mg/L for 1 hour
0.1
mg/L indefinite
0.1
mg/L OID Q3D for three treatments
|
fungi
fungi,
some bacteria, Ich, Cryptocaryon, Oodinium
|
Stains
skin and fabrics. Is mutagenic, teraogenic. May be toxic to some species
if overdosed. More toxic at higher temperatures. |